PKPD model for methacetin based liver function tests.

Description

This model is a physiological pharmacokinetic/pharmacodynamics model (PKPD) for the absorption, distribution, metabolism and elimination of methacetin, bicarbonate and paracetamol encoded in SBML format.

The content of this model has been carefully created in a manual research effort.
This file has been created by Matthias Koenig.

Terms of use

Copyright © 2018 Matthias Koenig.

Redistribution and use of any part of this model, with or without modification, are permitted provided that the following conditions are met:

  1. Redistributions of this SBML file must retain the above copyright notice, this list of conditions and the following disclaimer.
  2. Redistributions in a different form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.
This model is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.

Koenig Matthias konigmatt@googlemail.com Humboldt-University Berlin, Institute for Theoretical Biology 2018-02-26T19:16:14Z 2018-02-26T19:16:14Z x y x x y y x y x x y y 1 FVbo FVhe FVgu FVki FVli FVlu FVsp FVve FVar FVpl 1 FQbo FQhe FQgu FQki FQh FQsp 0.024265 BW 1 0.5378 HEIGHT 1 0.3964 BW COBW HR HRrest COHRI 60 CO 1000 3600 BSA P_CO2BSA 60 R_PDB 1 R_PDB P_CO2 Exhalation_co2c13 60 1 1 R_PDB P_CO2 P_CO2c13 P_CO2c12 P_CO2c13 P_CO2c12 P_CO2c13 P_CO2c13 P_CO2c12 R_PDB R_PDB 1000 BW FVbo BW FVhe BW FVgu BW FVki BW FVli BW FVlu BW FVsp BW FVve BW FVar BW FVpl BW FVre Vpl Vve Vve Var Vpl Var Vve Var QC FQbo QC FQhe QC FQgu QC FQki QC FQh Qh Qgu Qsp QC FQlu QC FQsp QC FQre Xar_metc13 Xbo_metc13 Xhe_metc13 Xgu_metc13 Xki_metc13 Xli_metc13 Xlu_metc13 Xsp_metc13 Xre_metc13 Xve_metc13 Cve_metc13 BP_metc13 Cli_metc13 fup_metc13 Cki_metc13 fup_metc13 1.386 ti_metc13 3600 Asp_metc13 Vsp Asp_metc13 Mr_metc13 Asp_metc13 Vsp Mr_metc13 Are_metc13 Vre Are_metc13 Mr_metc13 Are_metc13 Vre Mr_metc13 Ali_metc13 Vli Ali_metc13 Mr_metc13 Ali_metc13 Vli Mr_metc13 Ave_metc13 Vve Ave_metc13 Mr_metc13 Ave_metc13 Vve Mr_metc13 Abo_metc13 Vbo Abo_metc13 Mr_metc13 Abo_metc13 Vbo Mr_metc13 Aki_metc13 Vki Aki_metc13 Mr_metc13 Aki_metc13 Vki Mr_metc13 Alu_metc13 Vlu Alu_metc13 Mr_metc13 Alu_metc13 Vlu Mr_metc13 Agu_metc13 Vgu Agu_metc13 Mr_metc13 Agu_metc13 Vgu Mr_metc13 Ahe_metc13 Vhe Ahe_metc13 Mr_metc13 Ahe_metc13 Vhe Mr_metc13 Aar_metc13 Var Aar_metc13 Mr_metc13 Aar_metc13 Var Mr_metc13 Aurine_metc13 Mr_metc13 Xar_apap Xbo_apap Xhe_apap Xgu_apap Xki_apap Xli_apap Xlu_apap Xsp_apap Xre_apap Xve_apap Cve_apap BP_apap Cli_apap fup_apap Cki_apap fup_apap 1.386 ti_apap 3600 Asp_apap Vsp Asp_apap Mr_apap Asp_apap Vsp Mr_apap Are_apap Vre Are_apap Mr_apap Are_apap Vre Mr_apap Ali_apap Vli Ali_apap Mr_apap Ali_apap Vli Mr_apap Ave_apap Vve Ave_apap Mr_apap Ave_apap Vve Mr_apap Abo_apap Vbo Abo_apap Mr_apap Abo_apap Vbo Mr_apap Aki_apap Vki Aki_apap Mr_apap Aki_apap Vki Mr_apap Alu_apap Vlu Alu_apap Mr_apap Alu_apap Vlu Mr_apap Agu_apap Vgu Agu_apap Mr_apap Agu_apap Vgu Mr_apap Ahe_apap Vhe Ahe_apap Mr_apap Ahe_apap Vhe Mr_apap Aar_apap Var Aar_apap Mr_apap Aar_apap Var Mr_apap Aurine_apap Mr_apap Xar_co2c13 Xbo_co2c13 Xhe_co2c13 Xgu_co2c13 Xki_co2c13 Xli_co2c13 Xlu_co2c13 Xsp_co2c13 Xre_co2c13 Xve_co2c13 Cve_co2c13 BP_co2c13 Cli_co2c13 fup_co2c13 Cki_co2c13 fup_co2c13 1.386 ti_co2c13 3600 Asp_co2c13 Vsp Asp_co2c13 Mr_co2c13 Asp_co2c13 Vsp Mr_co2c13 Are_co2c13 Vre Are_co2c13 Mr_co2c13 Are_co2c13 Vre Mr_co2c13 Ali_co2c13 Vli Ali_co2c13 Mr_co2c13 Ali_co2c13 Vli Mr_co2c13 Ave_co2c13 Vve Ave_co2c13 Mr_co2c13 Ave_co2c13 Vve Mr_co2c13 Abo_co2c13 Vbo Abo_co2c13 Mr_co2c13 Abo_co2c13 Vbo Mr_co2c13 Aki_co2c13 Vki Aki_co2c13 Mr_co2c13 Aki_co2c13 Vki Mr_co2c13 Alu_co2c13 Vlu Alu_co2c13 Mr_co2c13 Alu_co2c13 Vlu Mr_co2c13 Agu_co2c13 Vgu Agu_co2c13 Mr_co2c13 Agu_co2c13 Vgu Mr_co2c13 Ahe_co2c13 Vhe Ahe_co2c13 Mr_co2c13 Ahe_co2c13 Vhe Mr_co2c13 Aar_co2c13 Var Aar_co2c13 Mr_co2c13 Aar_co2c13 Var Mr_co2c13 Aurine_co2c13 Mr_co2c13 Abreath_co2c13 Mr_co2c13 Abo_co2c13_fix Vbo Abo_co2c13_fix Mr_co2c13 Absorption_metc13 Mr_metc13 Injection_metc13 Mr_metc13 Ri_metc13 60 Absorption_apap Mr_apap Injection_apap Mr_apap Ri_apap 60 Absorption_co2c13 Mr_co2c13 Injection_co2c13 Mr_co2c13 Ri_co2c13 60 CYP1A2MET_CL fumic_metc13 MPPGL Vli F_PAR 60 1000 CO2FIX_HLM_CL MPPGL Vli F_PAR 60 1000 APAPD_HLM_CL fumic_apap MPPGL Vli F_PAR 60 1000 CYP1A2MET_CLliv 1 Cli_free_metc13 Cli_free_metc13 CYP1A2MET_Km_met CO2FIX_CLliv 1 Cli_co2c13 Cli_co2c13 CO2FIX_Km_co2 APAPD_CLliv 1 Cli_free_apap Cli_free_apap APAPD_Km_apap KLU_EXCO2 60 Clu_co2c13 Vlu KBO_FIXCO2 60 Cve_co2c13 Vve 1 Cbo_co2c13_fix KBO_MAXCO2 KBO_RELCO2 60 Cbo_co2c13_fix Vve Ki_metc13 IVDOSE_metc13 Mr_metc13 Ri_metc13 Mr_metc13 60 Ka_metc13 PODOSE_metc13 Mr_metc13 F_metc13 CLrenal_metc13 Cki_free_metc13 Qlu Cve_metc13 Qlu Clu_metc13 Kplu_metc13 BP_metc13 Qre Car_metc13 Qre Cre_metc13 Kpre_metc13 BP_metc13 Qbo Car_metc13 Qbo Cbo_metc13 Kpbo_metc13 BP_metc13 Qgu Car_metc13 Qgu Cgu_metc13 Kpgu_metc13 BP_metc13 Qhe Car_metc13 Qhe Che_metc13 Kphe_metc13 BP_metc13 Qki Car_metc13 Qki Cki_metc13 Kpki_metc13 BP_metc13 Qsp Car_metc13 Qsp Csp_metc13 Kpsp_metc13 BP_metc13 Qha Car_metc13 Qh Cli_metc13 Kpli_metc13 BP_metc13 Ki_apap IVDOSE_apap Mr_apap Ri_apap Mr_apap 60 Ka_apap PODOSE_apap Mr_apap F_apap CLrenal_apap Cki_free_apap Qlu Cve_apap Qlu Clu_apap Kplu_apap BP_apap Qre Car_apap Qre Cre_apap Kpre_apap BP_apap Qbo Car_apap Qbo Cbo_apap Kpbo_apap BP_apap Qgu Car_apap Qgu Cgu_apap Kpgu_apap BP_apap Qhe Car_apap Qhe Che_apap Kphe_apap BP_apap Qki Car_apap Qki Cki_apap Kpki_apap BP_apap Qsp Car_apap Qsp Csp_apap Kpsp_apap BP_apap Qha Car_apap Qh Cli_apap Kpli_apap BP_apap Ki_co2c13 IVDOSE_co2c13 Mr_co2c13 Ri_co2c13 Mr_co2c13 60 Ka_co2c13 PODOSE_co2c13 Mr_co2c13 F_co2c13 CLrenal_co2c13 Cki_free_co2c13 Qlu Cve_co2c13 Qlu Clu_co2c13 Kplu_co2c13 BP_co2c13 Qre Car_co2c13 Qre Cre_co2c13 Kpre_co2c13 BP_co2c13 Qbo Car_co2c13 Qbo Cbo_co2c13 Kpbo_co2c13 BP_co2c13 Qgu Car_co2c13 Qgu Cgu_co2c13 Kpgu_co2c13 BP_co2c13 Qhe Car_co2c13 Qhe Che_co2c13 Kphe_co2c13 BP_co2c13 Qki Car_co2c13 Qki Cki_co2c13 Kpki_co2c13 BP_co2c13 Qsp Car_co2c13 Qsp Csp_co2c13 Kpsp_co2c13 BP_co2c13 Qha Car_co2c13 Qh Cli_co2c13 Kpli_co2c13 BP_co2c13